Incredibly narrow and designed to improve motorcycle ergonomics and control, especially when braking and in a hanging-off position. The shape of the 17-litre aluminium tank, part of which extends under the seat as with the race bikes, allows the rider to assume the correct aerodynamic position along the straight while the deep hollows and side pads make for more effective braking, ensuring less strain on the arms and reducing physical effort. The upper lateral surfaces are also shaped to help the rider maintain a hanging-off position. At the front, the space not occupied by fuel has been used to house some of the electronics, improving weight distribution.

The seat has been completed revised to offer the rider all the room they need in different riding contexts. It is 35 mm longer to facilitate backwards movement and allow the rider to assume the correct aerodynamic position, and 50 mm wider to allow, in combination with the tank, for more natural movement in a hanging-off position.

The footpegs are positioned 10 mm further in on each side compared to the previous Panigale V4. This shift allows the rider to naturally assume a more aerodynamic position. Having the footpegs closer to the seat also makes for more responsive control.

Particular attention has been paid to thermal comfort, which is boosted thanks to a hot air extraction system at the rear bank. A pair of ducts integrated into the rear subframe merge into two outlets nestled in the undertail.